Reactome | RNASEL cleaves viral ssRNA

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:9009939] RNA endonuclease activity of RNASEL:2'-5' oligoadenylate [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9009930] Shamovsky, Veronica, 2017-06-23
dbId	9009941
displayName	RNASEL cleaves viral ssRNA
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
input	[GenomeEncodedEntity:R-FLU-9009966] FLUAV UpN-ssRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009965] RNase L targets distinct sites in influenza A virus RNAs
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNASEL cleaves viral ssRNA RNASEL cleaves viral ssRNA to generate 5'-OH, 2'-3' cyclic phosphate RNA fragments
output	[OtherEntity:R-ALL-9009945] RNA fragment with 2'-3' cyclic phosphate [cytosol]
precedingEvent	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate - Homo sapiens
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9009941
summation	[Summation:9009957] Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain c...

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