Reactome | IL37(?-218) binds p-S423,S425-SMAD3

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IL37(?-218) binds p-S423,S425-SMAD3 Show undefined attributes

authored	[InstanceEdit:9023343] Varusai, Thawfeek, 2017-09-27
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9009907] Varusai, Thawfeek, 2017-06-23
dbId	9009910
displayName	IL37(?-218) binds p-S423,S425-SMAD3
edited	[InstanceEdit:9023343] Varusai, Thawfeek, 2017-09-27
eventOf	[Pathway:R-HSA-9008059] Interleukin-37 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9008928] IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9008692] IL37(?-218) binds SMAD3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9008584] IL37(?-218) [cytosol] [EntityWithAccessionedSequence:R-HSA-171184] p-S423,S425-SMAD3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9008700] IL-37 is a fundamental inhibitor of innate immunity [LiteratureReference:9008683] Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	IL37(?-218) binds p-S423,S425-SMAD3 IL-37(?-218) binds p-S423,S425-SMAD3
orthologousEvent	[Reaction:R-BTA-9009910] IL37(?-218) binds p-S423,S425-SMAD3 - Bos taurus [Reaction:R-DRE-9009910] IL37(?-218) binds p-S423,S425-SMAD3 - Danio rerio [Reaction:R-CFA-9009910] IL37(?-218) binds p-S423,S425-SMAD3 - Canis familiaris
output	[Complex:R-HSA-9009901] IL37(?-218):p-S423,S425-SMAD3 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9012689] IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027502] Carriero, Roberta, 2017-11-02 [InstanceEdit:9027496] Garlanda, Cecilia, 2017-11-02 [InstanceEdit:9027499] Mantovani, Alberto, 2017-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009910
summation	[Summation:9009906] Interleukins (IL) are immunomodulatory proteins that elicit ...

Referrals

(hasEvent)	[Pathway:R-HSA-9008059] Interleukin-37 signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9008928] IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus [Reaction:R-HSA-9008692] IL37(?-218) binds SMAD3

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