Reactome | OAS1 produces oligoadenylates

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OAS1 produces oligoadenylates Show undefined attributes

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:8983641] 2'-5'-oligoadenylate synthetase activity of OAS1 tetramer:OAS1 ligand [cytosol]
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8983701] Shamovsky, Veronica, 2017-03-27
dbId	8983680
displayName	OAS1 produces oligoadenylates
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
followingEvent	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8983650] Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1 [LiteratureReference:9012236] The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	OAS1 produces oligoadenylates
output	[Polymer:R-HSA-8983696] 2'-5' oligoadenylate [cytosol] 2 × [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-8983688] OAS1 oligomerizes - Homo sapiens
relatedSpecies	[Species:8983661] Dengue virus [Species:8983693] Tick-borne encephalitis virus [Species:8983656] West Nile virus
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-8983680
summation	[Summation:9012240] Oligoadenylate synthetase 1 (OAS1) produces the second messe...

Referrals

(precedingEvent)	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate
(hasEvent)	[Pathway:R-HSA-8983711] OAS antiviral response

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