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Schema
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Reaction
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Entries
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
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authored
[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
catalystActivity
[CatalystActivity:8964621] guanyl-nucleotide exchange factor activity of G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:8964631] Varusai, Thawfeek, 2017-02-17
dbId
8964604
displayName
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
edited
[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
eventOf
[Pathway:R-HSA-8964616] G beta:gamma signalling through CDC42 - Homo sapiens
followingEvent
[Reaction:R-HSA-8964614] PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated - Homo sapiens
input
[Complex:R-HSA-8964627] G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8964617] Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
orthologousEvent
[Reaction:R-CEL-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Caenorhabditis elegans
[Reaction:R-DME-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Drosophila melanogaster
[Reaction:R-GGA-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Gallus gallus
[Reaction:R-XTR-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Xenopus tropicalis
[Reaction:R-SSC-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Sus scrofa
[Reaction:R-BTA-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Bos taurus
[Reaction:R-CFA-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Canis familiaris
[Reaction:R-RNO-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Rattus norvegicus
[Reaction:R-MMU-8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated - Mus musculus
output
[Complex:R-HSA-8964618] G-protein beta-gamma complex:PAK1:ARHGEF6:Active CDC42 [plasma membrane]
precedingEvent
[Reaction:R-HSA-8964634] CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex - Homo sapiens
releaseDate
2018-12-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9617615] Goedhart, Joachim, 2018-08-29
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8964604
summation
[Summation:8964600] G-Protein Coupled Receptors (GPCR) sense extracellular signa...
Referrals
(precedingEvent)
[Reaction:R-HSA-8964614] PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
(hasEvent)
[Pathway:R-HSA-8964616] G beta:gamma signalling through CDC42
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