Reactome | E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961867] Orlic-Milacic, Marija, 2017-02-06
dbId	8961860
displayName	E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-8954061] DHFR gene [nucleoplasm] [Complex:R-HSA-68653] E2F1:TFDP1,TFDP2 [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961868] Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1 [LiteratureReference:8961854] Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition
maxDepth	4
name	E2F1:TFDP1,TFDP2:DHFR gene
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-8961875] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-8961863] E2F1 binds the DHFR gene promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8961860

(regulator)	[PositiveGeneExpressionRegulation:R-HSA-8961875] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]'
(output)	[Reaction:R-HSA-8961863] E2F1 binds the DHFR gene promoter

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