Reactome | EBI3:CANX binds IL12A

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EBI3:CANX binds IL12A Show undefined attributes

authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
category	uncertain
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950362
displayName	EBI3:CANX binds IL12A
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
eventOf	[Pathway:R-HSA-8984722] Interleukin-35 Signalling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8950740] CANX dissociates from IL12A:EBI3 - Homo sapiens
input	[Complex:R-HSA-8950369] CANX:EBI3 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8950139] IL12A [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809130] The inhibitory cytokine IL-35 contributes to regulatory T-cell function [LiteratureReference:8949818] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [LiteratureReference:8950187] Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	EBI3:CANX binds IL12A
orthologousEvent	[BlackBoxEvent:R-SSC-8950362] EBI3:CANX binds IL12A - Sus scrofa [BlackBoxEvent:R-BTA-8950362] EBI3:CANX binds IL12A - Bos taurus [BlackBoxEvent:R-CFA-8950362] EBI3:CANX binds IL12A - Canis familiaris [BlackBoxEvent:R-RNO-8950362] EBI3:CANX binds IL12A - Rattus norvegicus [BlackBoxEvent:R-MMU-8950362] EBI3:CANX binds IL12A - Mus musculus
output	[Complex:R-HSA-8950383] CANX:EBI3:IL12A [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-8950387] CANX binds EBI3 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8950362
summation	[Summation:8950621] Interleukin-35 is a heterodimer of Interleukin-27 subunit be...

Referrals

(hasEvent)	[Pathway:R-HSA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-HSA-8950740] CANX dissociates from IL12A:EBI3