Reactome | Association of procollagen type VI

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Association of procollagen type VI Show undefined attributes

authored	[InstanceEdit:2192896] Jupe, S, 2012-04-11
category	binding
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:8944228] Jupe, Steve, 2016-11-03
dbId	8944247
displayName	Association of procollagen type VI
edited	[InstanceEdit:8944470] Jupe, Steve, 2016-11-03
eventOf	[Pathway:R-HSA-8948216] Collagen chain trimerization - Homo sapiens
followingEvent	[Reaction:R-HSA-2022073] Procollagen triple helix formation - Homo sapiens
input	[DefinedSet:R-HSA-2025746] Alpha-1(VI) chains [endoplasmic reticulum lumen] [DefinedSet:R-HSA-2025747] Alpha-2(VI) chains [endoplasmic reticulum lumen] [CandidateSet:R-HSA-2025754] Alpha-3-6(VI) propeptides [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2008097] Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain [LiteratureReference:2008075] The role of cis-trans isomerization of peptide bonds in the coil leads to and comes from triple helix conversion of collagen
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Association of procollagen type VI
orthologousEvent	[Reaction:R-DDI-8944247] Association of procollagen type VI - Dictyostelium discoideum [Reaction:R-CEL-8944247] Association of procollagen type VI - Caenorhabditis elegans [Reaction:R-SSC-8944247] Association of procollagen type VI - Sus scrofa [Reaction:R-BTA-8944247] Association of procollagen type VI - Bos taurus [Reaction:R-MMU-8944247] Association of procollagen type VI - Mus musculus
output	[Complex:R-HSA-2025770] C-linked procollagen type VI trimer [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-8948231] COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [BlackBoxEvent:R-HSA-8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases - Homo sapiens [BlackBoxEvent:R-HSA-8948234] P4HB:4-Hyp collagen propeptides dissociates - Homo sapiens [BlackBoxEvent:R-HSA-8948222] PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [BlackBoxEvent:R-HSA-8948224] PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens [BlackBoxEvent:R-HSA-8948226] Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2267224] Canty-Laird, EG, 2012-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8944247
summation	[Summation:8944239] The C-terminal propeptide region is required for the associa...

Referrals

(hasEvent)	[Pathway:R-HSA-8948216] Collagen chain trimerization
(precedingEvent)	[Reaction:R-HSA-2022073] Procollagen triple helix formation