Reactome | TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane]

Schema > Complex > Entries

compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8943110] May, Bruce, 2016-10-24
dbId	8943070
displayName	TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-6781898] DERL1 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-8943134] TMEM129 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-8862601] UBE2J2-1 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-8943105] VCP [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-8943099] VIMP [endoplasmic reticulum membrane]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:8943130] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation [LiteratureReference:8943094] TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
maxDepth	2
modified	[InstanceEdit:8955688] May, Bruce, 2017-01-12
name	TMEM129:DERL1:VIMP:VCP:UBE2J2
producedByEvent	[BlackBoxEvent:R-HSA-8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8943070
updateTrackers	[UpdateTracker:9899557] Update Tracker - [Complex:8943070] TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] - v66:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9899557] Update Tracker - [Complex:8943070] TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] - v66:[updateContainedComponent]
(output)	[BlackBoxEvent:R-HSA-8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11