Reactome | POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1

Schema > Reaction > Entries

POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 Show undefined attributes

authored	[InstanceEdit:8931674] Jassal, Bijay, 2016-07-18
catalystActivity	[CatalystActivity:8931636] mannokinase activity of POMK [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8931674] Jassal, Bijay, 2016-07-18
crossReference	[DatabaseIdentifier:9940876] RHEA:52617
dbId	8931653
displayName	POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1
edited	[InstanceEdit:8931674] Jassal, Bijay, 2016-07-18
eventOf	[Pathway:R-HSA-8932505] DAG1 core M3 glycosylations - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9940714] Glycosylated alpha-DAG1 localizes to Golgi - Homo sapiens
input	[SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8931656] GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8879116] SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function [LiteratureReference:8931663] POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1
orthologousEvent	[Reaction:R-GGA-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Gallus gallus [Reaction:R-XTR-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Xenopus tropicalis [Reaction:R-DRE-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Danio rerio [Reaction:R-SSC-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Sus scrofa [Reaction:R-BTA-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Bos taurus [Reaction:R-CFA-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Canis familiaris [Reaction:R-RNO-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Rattus norvegicus [Reaction:R-MMU-8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - Mus musculus
output	[SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8931659] GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-8931648] B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934767] D'Eustachio, Peter, 2016-08-12 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08 [InstanceEdit:9947107] Zaru, Rossana, 2025-05-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8931653
summation	[Summation:8931660] Protein O-mannose kinase (POMK, SGK196) phosphorylates posit...
updateTrackers	[UpdateTracker:9953598] Update Tracker - [Reaction:8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - v93:[modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953598] Update Tracker - [Reaction:8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 - v93:[modifyText, removeOutput]
(hasEvent)	[Pathway:R-HSA-8932505] DAG1 core M3 glycosylations
(precedingEvent)	[BlackBoxEvent:R-HSA-9940714] Glycosylated alpha-DAG1 localizes to Golgi