Reactome | MET activates STAT3

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MET activates STAT3 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:8875798] Orlic-Milacic, Marija, 2016-06-08
dbId	8875791
displayName	MET activates STAT3
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8875816] STAT3 binds activated MET receptor - Homo sapiens [Reaction:R-HSA-8875817] MET phosphorylates STAT3 - Homo sapiens [Reaction:R-HSA-2730595] Phosphorylated STAT3 Forms Dimers - Homo sapiens [BlackBoxEvent:R-HSA-2730599] Phosphorylated STAT3 Dimer Translocates to the Nucleus - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875792] STAT 1alpha/1beta, STAT 3 and STAT 5: expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes [LiteratureReference:8875769] Induction of epithelial tubules by growth factor HGF depends on the STAT pathway [LiteratureReference:8875787] Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis [LiteratureReference:8875801] Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3 [LiteratureReference:8875777] A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells [LiteratureReference:8875779] A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells [LiteratureReference:8875784] Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation [LiteratureReference:8931920] Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MET activates STAT3
orthologousEvent	[Pathway:R-GGA-8875791] MET activates STAT3 - Gallus gallus [Pathway:R-XTR-8875791] MET activates STAT3 - Xenopus tropicalis [Pathway:R-SSC-8875791] MET activates STAT3 - Sus scrofa [Pathway:R-BTA-8875791] MET activates STAT3 - Bos taurus [Pathway:R-CFA-8875791] MET activates STAT3 - Canis familiaris [Pathway:R-RNO-8875791] MET activates STAT3 - Rattus norvegicus [Pathway:R-MMU-8875791] MET activates STAT3 - Mus musculus
releaseDate	2016-09-19
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8875791
summation	[Summation:8875810] The STAT3 transcription factor binds to activated MET throug...

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[Pathway:R-HSA-6806834] Signaling by MET

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