Reactome | EGFR phosphorylates EPS15

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EGFR phosphorylates EPS15 Show undefined attributes

authored	[InstanceEdit:8866957] Rothfels, Karen, 2016-04-05
catalystActivity	[CatalystActivity:8867039] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8867043] Rothfels, Karen, 2016-04-05
dbId	8867041
displayName	EGFR phosphorylates EPS15
edited	[InstanceEdit:8866957] Rothfels, Karen, 2016-04-05
eventOf	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent	[Reaction:R-HSA-8867047] PTPN3 dephosphorylates EPS15 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8866989] Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis [LiteratureReference:8866987] Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment [LiteratureReference:8866997] Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation [LiteratureReference:8867017] Eps15: a multifunctional adaptor protein regulating intracellular trafficking
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	EGFR phosphorylates EPS15
negativePrecedingEvent	[NegativePrecedingEvent:9865813] Futile Cycle: PTPN3 dephosphorylates EPS15
orthologousEvent	[Reaction:R-RNO-8867041] EGFR phosphorylates EPS15 - Rattus norvegicus [Reaction:R-CEL-8867041] EGFR phosphorylates EPS15 - Caenorhabditis elegans [Reaction:R-DME-8867041] EGFR phosphorylates EPS15 - Drosophila melanogaster [Reaction:R-GGA-8867041] EGFR phosphorylates EPS15 - Gallus gallus [Reaction:R-SSC-8867041] EGFR phosphorylates EPS15 - Sus scrofa [Reaction:R-BTA-8867041] EGFR phosphorylates EPS15 - Bos taurus [Reaction:R-CFA-8867041] EGFR phosphorylates EPS15 - Canis familiaris [Reaction:R-MMU-8867041] EGFR phosphorylates EPS15 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane]
precedingEvent	[Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869706] Chen, Guang-Chao, 2016-05-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8867041
summation	[Summation:8867040] EPS15 is phosphorylated at Y849 by activated EGFR (Confaloni...

Referrals

(hasEvent)	[Pathway:R-HSA-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-HSA-8867047] PTPN3 dephosphorylates EPS15