Reactome | ub-CFTR F508del [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-HSA-8866858] CFTR F508del is degraded by the 26S proteasome - Homo sapiens
created	[InstanceEdit:8866843] Rothfels, Karen, 2016-04-04
crossReference	[DatabaseIdentifier:12020976] Mondo:0009061
dbId	8866844
disease	[Disease:5678942] cystic fibrosis
displayName	ub-CFTR F508del [cytosol]
hasComponent	[DefinedSet:R-HSA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-8866838] ub-CFTR F508del [cytosol]
inDisease	true
isChimeric	false
maxDepth	3
modified	[InstanceEdit:9634794] Rothfels, Karen, 2019-01-15
name	ub-CFTR F508del
producedByEvent	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8866844
updateTrackers	[UpdateTracker:9900099] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v68:[add_removeHasComponent] [UpdateTracker:9897294] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v61:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9900099] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v68:[add_removeHasComponent] [UpdateTracker:9897294] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v61:[updateContainedComponent]
(input)	[BlackBoxEvent:R-HSA-8866858] CFTR F508del is degraded by the 26S proteasome
(diseaseEntity)	[EntityFunctionalStatus:9630131] gain_of_function of ub-CFTR F508del [cytosol]
(output)	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol