Reactome | EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

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EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8864117] Orlic-Milacic, Marija, 2016-03-11
dbId	8864124
displayName	EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
hasComponent	[Complex:R-HSA-1248702] EGF:p-6Y-EGFR [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8864084] p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Mus musculus [Complex:R-RNO-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Canis familiaris [Complex:R-SSC-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Sus scrofa [Complex:R-GGA-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Gallus gallus [Complex:R-DME-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-8864124] EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:8864080] Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
maxDepth	3
memberOf	[CandidateSet:R-HSA-8864120] Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane] - Homo sapiens
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	EGF:p-6Y-EGFR:p-Y1023,Y1139,Y1221,Y1222-ERBB2
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8864124

Referrals

(hasMember)

[CandidateSet:R-HSA-8864120] Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers [plasma membrane]

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