Reactome | PTPN12 dephosphorylates EGFR at Y1172 (Y1148)

Schema > Reaction > Entries

PTPN12 dephosphorylates EGFR at Y1172 (Y1148) Show undefined attributes

authored	[InstanceEdit:8864035] Orlic-Milacic, Marija, 2016-03-10
catalystActivity	[CatalystActivity:8863802] protein tyrosine phosphatase activity of PTPN12 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643236] protein tyrosine phosphatase activity of PTPN12 [cytosol] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8864027] Orlic-Milacic, Marija, 2016-03-10
dbId	8864029
displayName	PTPN12 dephosphorylates EGFR at Y1172 (Y1148)
edited	[InstanceEdit:8934524] Orlic-Milacic, Marija, 2016-08-09
eventOf	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2455327] negative regulation of ERBB signaling pathway
input	[Complex:R-HSA-179882] EGF:p-6Y-EGFR dimer [plasma membrane] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8863803] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase [LiteratureReference:8933605] The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor [LiteratureReference:8933614] The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PTPN12 dephosphorylates EGFR at Y1172 (Y1148)
orthologousEvent	[Reaction:R-RNO-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Rattus norvegicus [Reaction:R-GGA-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Gallus gallus [Reaction:R-XTR-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Xenopus tropicalis [Reaction:R-SSC-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Sus scrofa [Reaction:R-CFA-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Canis familiaris [Reaction:R-MMU-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Mus musculus
output	[Complex:R-HSA-8864028] EGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148) [plasma membrane] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934523] Ayoub, Emily, 2016-08-04 [InstanceEdit:8934520] Tremblay, Michel, 2016-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8864029
summation	[Summation:8864033] PTPN12 protein tyrosine phosphatase dephosphorylates activat...
updateTrackers	[UpdateTracker:9846636] Update Tracker - [Reaction:8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846636] Update Tracker - [Reaction:8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - v84:[modifyText]
(hasEvent)	[Pathway:R-HSA-182971] EGFR downregulation