Reactome | JAK2 is phosphorylated, activated

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JAK2 is phosphorylated, activated Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:914083] non-membrane spanning protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
dbId	879910
displayName	JAK2 is phosphorylated, activated
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-879930] STAT5 is recruited by JAK2 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:879936] JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	JAK2 is phosphorylated, activated
orthologousEvent	[Reaction:R-GGA-879910] JAK2 is phosphorylated, activated - Gallus gallus [Reaction:R-SSC-879910] JAK2 is phosphorylated, activated - Sus scrofa [Reaction:R-BTA-879910] JAK2 is phosphorylated, activated - Bos taurus [Reaction:R-CFA-879910] JAK2 is phosphorylated, activated - Canis familiaris [Reaction:R-RNO-879910] JAK2 is phosphorylated, activated - Rattus norvegicus [Reaction:R-MMU-879910] JAK2 is phosphorylated, activated - Mus musculus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-913405] High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-879942] The receptor is activated - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-879910
summation	[Summation:879955] JAK2 is tyrosine phosphorylated in response to IL-3 (Silvenn...
updateTrackers	[UpdateTracker:9789986] Update Tracker - [Reaction:879910] JAK2 is phosphorylated, activated - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789986] Update Tracker - [Reaction:879910] JAK2 is phosphorylated, activated - v36:[modifyText]
(hasEvent)	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)	[Reaction:R-HSA-879930] STAT5 is recruited by JAK2