Reactome | myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2

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myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 Show undefined attributes

catalystActivity	[CatalystActivity:77259] acyl-CoA dehydrogenase activity of ACADL tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667499] RHEA:28359 [DatabaseIdentifier:9977646] RHEA:47317
dbId	77274
displayName	myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2
eventOf	[Pathway:R-HSA-77285] Beta oxidation of myristoyl-CoA to lauroyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77277] trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoA - Homo sapiens [Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-77272] MYS-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77398] On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein. [LiteratureReference:77400] Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 tetradecanoyl-CoA + oxidized (electron-transfer flavoprotein) + H(+) => (2E)-tetradecenoyl-CoA + reduced (electron-transfer flavoprotein)
orthologousEvent	[Reaction:R-DRE-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Danio rerio [Reaction:R-GGA-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Gallus gallus [Reaction:R-XTR-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Xenopus tropicalis [Reaction:R-SSC-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Sus scrofa [Reaction:R-BTA-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Bos taurus [Reaction:R-CFA-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Canis familiaris [Reaction:R-RNO-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Rattus norvegicus [Reaction:R-MMU-77274] myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2 - Mus musculus
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-77273] trans-Tetradec-2-enoyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77304] 3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77274
summation	[Summation:178958] ACADL in the mitochondrial matrix dehydrogenates palmitoyl-C...
updateTrackers	[UpdateTracker:9984643] Update Tracker - [Reaction:77274] myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 - v96:[modifyText, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9984643] Update Tracker - [Reaction:77274] myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 - v96:[modifyText, removeInput]
(hasEvent)	[Pathway:R-HSA-77285] Beta oxidation of myristoyl-CoA to lauroyl-CoA
(precedingEvent)	[Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF [Reaction:R-HSA-77277] trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoA

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