Reactome | lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2

Schema > Reaction > Entries

lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 Show undefined attributes

catalystActivity	[CatalystActivity:77259] acyl-CoA dehydrogenase activity of ACADL tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667503] RHEA:31040 [DatabaseIdentifier:9977651] RHEA:31040
dbId	77263
displayName	lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2
eventOf	[Pathway:R-HSA-77310] Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77256] 2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA - Homo sapiens [Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-77261] LAU-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77398] On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein. [LiteratureReference:77400] Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2
orthologousEvent	[Reaction:R-DRE-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Danio rerio [Reaction:R-GGA-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Gallus gallus [Reaction:R-XTR-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Xenopus tropicalis [Reaction:R-SSC-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Sus scrofa [Reaction:R-BTA-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Bos taurus [Reaction:R-CFA-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Canis familiaris [Reaction:R-RNO-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Rattus norvegicus [Reaction:R-MMU-77263] lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2 - Mus musculus
output	[SimpleEntity:R-ALL-77255] 2-trans-Dodecenoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77271] 3-Oxotetradecanoyl-CoA+CoA-SH => Lauroyl-CoA + acetyl-CoA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77263
summation	[Summation:178928] ACADL in the mitochondrial matrix dehydrogenates lauroyl-CoA...
updateTrackers	[UpdateTracker:9984662] Update Tracker - [Reaction:77263] lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 - v96:[modifyText, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9984662] Update Tracker - [Reaction:77263] lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 - v96:[modifyText, removeInput]
(hasEvent)	[Pathway:R-HSA-77310] Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
(precedingEvent)	[Reaction:R-HSA-169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF [Reaction:R-HSA-77256] 2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA