Reactome | Liganded Gz-activating GPCR acts as a GEF for Gz

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Liganded Gz-activating GPCR acts as a GEF for Gz Show undefined attributes

authored	[InstanceEdit:392024] Jupe, S, 2009-02-26 15:51:29
catalystActivity	[CatalystActivity:392856] guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
dbId	749453
displayName	Liganded Gz-activating GPCR acts as a GEF for Gz
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-418597] G alpha (z) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-749450] Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:435188] G(z) signaling: emerging divergence from G(i) signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded Gz-activating GPCR acts as a GEF for Gz
orthologousEvent	[Reaction:R-CEL-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Caenorhabditis elegans [Reaction:R-DME-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Drosophila melanogaster [Reaction:R-GGA-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Gallus gallus [Reaction:R-XTR-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Xenopus tropicalis [Reaction:R-DRE-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Danio rerio [Reaction:R-SSC-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Sus scrofa [Reaction:R-BTA-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Bos taurus [Reaction:R-CFA-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Canis familiaris [Reaction:R-RNO-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Rattus norvegicus [Reaction:R-MMU-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Mus musculus
output	[Complex:R-HSA-751030] ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-HSA-749446] Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-749453
summation	[Summation:751022] The liganded receptor undergoes a conformational change, gen...
updateTrackers	[UpdateTracker:9781759] Update Tracker - [Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz - v60:[modifyText] [UpdateTracker:9939745] Update Tracker - [Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781759] Update Tracker - [Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz - v60:[modifyText] [UpdateTracker:9939745] Update Tracker - [Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz - v92:[modifyText]
(hasEvent)	[Pathway:R-HSA-418597] G alpha (z) signalling events
(precedingEvent)	[Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates