Reactome | Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter

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Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter Show undefined attributes

authored	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
category	binding
compartment	[Compartment:350] nucleolus
created	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
dbId	73739
displayName	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73762] RNA Polymerase I Transcription Initiation - Homo sapiens
figure	[Figure:75834] /figures/PolI_txn_SL1recruitment.jpg
followingEvent	[Reaction:R-HSA-73758] Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter - Homo sapiens
input	[Complex:R-HSA-73693] Acetylated SL1 [nucleoplasm] [Complex:R-HSA-73685] Phosphorylated UBF-1:rDNA promoter [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:73740] Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. [LiteratureReference:73742] Coactivator and promoter-selective properties of RNA polymerase I TAFs. [LiteratureReference:73744] Repression of RNA polymerase I transcription by the tumor suppressor p53.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
orthologousEvent	[Reaction:R-GGA-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Gallus gallus [Reaction:R-SSC-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Sus scrofa [Reaction:R-BTA-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Bos taurus [Reaction:R-CFA-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Canis familiaris [Reaction:R-RNO-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Rattus norvegicus [Reaction:R-MMU-73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - Mus musculus
output	[Complex:R-HSA-73694] Acetylayed SL1:PhosUBF-1:rDNA promoter [nucleoplasm]
precedingEvent	[Reaction:R-HSA-73736] Acetylation of SL1 - Homo sapiens [Reaction:R-HSA-73722] Phosphorylation of UBF-1:rDNA Promoter - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-427325] Positive regulation by 'TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73739
summation	[Summation:73746] Human SL1 does not bind to DNA itself, rather it is recruite... [Summation:427338] Knockdown of CSB reduces recruitment of SL1 and RNA Polymera...
updateTrackers	[UpdateTracker:9775982] Update Tracker - [Reaction:73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - v78:[addSummation] [UpdateTracker:9791402] Update Tracker - [Reaction:73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - v30:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9775982] Update Tracker - [Reaction:73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - v78:[addSummation] [UpdateTracker:9791402] Update Tracker - [Reaction:73739] Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter - v30:[addRegulator]
(hasEvent)	[Pathway:R-HSA-73762] RNA Polymerase I Transcription Initiation
(precedingEvent)	[Reaction:R-HSA-73758] Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter

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