Reactome | CPSF [nucleoplasm]

Schema > Complex > Entries

CPSF [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-112160] CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-112164] upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-77589] Recognition of AAUAAA sequence by CPSF - Homo sapiens
dbId	71995
displayName	CPSF [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-71989] CPSF1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71991] CPSF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71993] CPSF3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-169104] CPSF4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6805150] FIP1L1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4615988] SYMPK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8938784] WDR33 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-71995] CPSF [nucleoplasm] - Mus musculus [Complex:R-RNO-71995] CPSF [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-71995] CPSF [nucleoplasm] - Canis familiaris [Complex:R-BTA-71995] CPSF [nucleoplasm] - Bos taurus [Complex:R-SSC-71995] CPSF [nucleoplasm] - Sus scrofa [Complex:R-DRE-71995] CPSF [nucleoplasm] - Danio rerio [Complex:R-XTR-71995] CPSF [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-71995] CPSF [nucleoplasm] - Gallus gallus [Complex:R-DME-71995] CPSF [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-71995] CPSF [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-71995] CPSF [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-71995] CPSF [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-71995] CPSF [nucleoplasm] - Saccharomyces cerevisiae
literatureReference	[LiteratureReference:6805149] Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase [LiteratureReference:8938798] Molecular architecture of the human pre-mRNA 3' processing complex [LiteratureReference:8938788] Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33
maxDepth	2
modified	[InstanceEdit:8938810] May, Bruce, 2016-09-12
name	CPSF Cleavage and polyadenylation specificity factor
producedByEvent	[Reaction:R-HSA-77594] Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-71995
updateTrackers	[UpdateTracker:9895270] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v59:[addHasComponent, addLiteratureReference] [UpdateTracker:9894537] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v57:[add_removeHasComponent] [UpdateTracker:9893125] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v55:[addHasComponent, addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9895270] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v59:[addHasComponent, addLiteratureReference] [UpdateTracker:9894537] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v57:[add_removeHasComponent] [UpdateTracker:9893125] Update Tracker - [Complex:71995] CPSF [nucleoplasm] - v55:[addHasComponent, addLiteratureReference]
(hasComponent)	[Complex:R-HSA-112164] upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] [Complex:R-HSA-112160] CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] [Complex:R-HSA-112167] Mature intronless derived mRNA complex [nucleoplasm] [Complex:R-HSA-72021] Cleavage and Polyadenylation Complex [nucleoplasm]
(input)	[Reaction:R-HSA-77589] Recognition of AAUAAA sequence by CPSF
(output)	[Reaction:R-HSA-77594] Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC

© 2026 Reactome

Cite Us!