Reactome | ethanol + NAD+ => acetaldehyde + NADH + H+

Schema > Reaction > Entries

ethanol + NAD+ => acetaldehyde + NADH + H+ Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:71694] alcohol dehydrogenase (NAD+) activity of alcohol dehydrogenase complex [cytosol]
catalystActivityReference	[CatalystActivityReference:9643878] alcohol dehydrogenase (NAD+) activity of alcohol dehydrogenase complex [cytosol] Human liver alcohol dehydrogenase: purification, composition, and catalytic features
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12668052] RHEA:25291
dbId	71707
deleted	[Deleted:449887] Deletion of instances: 142045, 71338 [Deleted:449889] Deletion of instances: 71764, 71763, 71717, 71712, 71711, 71710, 71709, 71708
displayName	ethanol + NAD+ => acetaldehyde + NADH + H+
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-71384] Ethanol oxidation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-449872] acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] - Homo sapiens [Reaction:R-HSA-71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] - Homo sapiens
input	[SimpleEntity:R-ALL-30203] EtOH [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71715] Human liver pi-alcohol dehydrogenase: kinetic and molecular properties [LiteratureReference:199885] Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene [LiteratureReference:71359] Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism [LiteratureReference:71344] Regulation of the mammalian alcohol dehydrogenase genes [LiteratureReference:71339] Human liver alcohol dehydrogenase: purification, composition, and catalytic features [LiteratureReference:71346] Isolation of pi-alcohol dehydrogenase of human liver: is it a determinant of alcoholism? [LiteratureReference:71755] Purification and characterization of a new alcohol dehydrogenase from human stomach [LiteratureReference:71353] Ontogenetic, polymorphic, and interethnic variation in the isoenzymes of human alcohol dehydrogenase [LiteratureReference:71350] Studies on the subunit structure and molecular size of the human alcohol dehydrogenase isozymes determined by the different loci, ADH1, ADH2, and ADH3 [LiteratureReference:71356] Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 "Oriental" isoenzymes [LiteratureReference:71758] Molecular cloning of human class IV alcohol dehydrogenase cDNA
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ethanol + NAD+ => acetaldehyde + NADH + H+ Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+
orthologousEvent	[Reaction:R-MMU-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Mus musculus [Reaction:R-SCE-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Saccharomyces cerevisiae [Reaction:R-SPO-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Schizosaccharomyces pombe [Reaction:R-DDI-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Gallus gallus [Reaction:R-XTR-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Danio rerio [Reaction:R-SSC-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Sus scrofa [Reaction:R-BTA-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Bos taurus [Reaction:R-CFA-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Canis familiaris [Reaction:R-RNO-71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - Rattus norvegicus
output	[SimpleEntity:R-ALL-29510] CH3CHO [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:449910] D'Eustachio, P, 2009-12-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71707
summation	[Summation:178703] Cytosolic alcohol dehydrogenase catalyzes the reaction of et...
updateTrackers	[UpdateTracker:9790905] Update Tracker - [Reaction:71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792309] Update Tracker - [Reaction:71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - v22:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790905] Update Tracker - [Reaction:71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792309] Update Tracker - [Reaction:71707] ethanol + NAD+ => acetaldehyde + NADH + H+ - v22:[addLiteratureReference]
(replacementInstances)	[Deleted:449887] Deletion of instances: 142045, 71338 [Deleted:449889] Deletion of instances: 71764, 71763, 71717, 71712, 71711, 71710, 71709, 71708
(hasEvent)	[Pathway:R-HSA-71384] Ethanol oxidation
(precedingEvent)	[BlackBoxEvent:R-HSA-449872] acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] [Reaction:R-HSA-71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

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