Reactome | Inactive BRAF mutants bind mutant RAS:GTP

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Inactive BRAF mutants bind mutant RAS:GTP Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802936] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802937
disease	[Disease:1500689] cancer
displayName	Inactive BRAF mutants bind mutant RAS:GTP
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6802880] gain_of_function of genetically or chemically inactive BRAF [cytosol]
eventOf	[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF - Homo sapiens
followingEvent	[Reaction:R-HSA-8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1 - Homo sapiens
input	[DefinedSet:R-HSA-6802631] genetically or chemically inactive BRAF [cytosol] [Complex:R-HSA-6802607] RAS mutants:GTP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF [LiteratureReference:6790390] RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF [LiteratureReference:6790370] RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inactive BRAF mutants bind mutant RAS:GTP
normalReaction	[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP
output	[Complex:R-HSA-8936725] chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-8936744] Positive regulation by 'PHB [cytosol]'
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802937
summation	[Summation:6802246] The paradoxical activation of ERK signaling downstream of ki...

Referrals

(hasEvent)	[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF
(precedingEvent)	[Reaction:R-HSA-8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1