Reactome | p-BRAF and RAF fusion dimers phosphorylate MAP2Ks

Schema > Reaction > Entries

p-BRAF and RAF fusion dimers phosphorylate MAP2Ks Show undefined attributes

authored	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
catalystActivity	[CatalystActivity:6802848] protein serine/threonine kinase activity of p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802931] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802933
disease	[Disease:1500689] cancer
displayName	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6802900] gain_of_function of p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol]
eventOf	[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions - Homo sapiens
followingEvent	[Reaction:R-HSA-6802935] MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6800638] Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas [LiteratureReference:6800633] Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma [LiteratureReference:6800635] Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma [LiteratureReference:6802072] Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer [LiteratureReference:6800639] The landscape of kinase fusions in cancer [LiteratureReference:6800632] BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition [LiteratureReference:6802135] Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas [LiteratureReference:6800629] A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation [LiteratureReference:6802031] Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
normalReaction	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-6802710] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol]
precedingEvent	[Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802933
summation	[Summation:6802184] BRAF and RAF fusion dimers constitutively phosphorylate MAP2...

Referrals

(hasEvent)	[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions
(precedingEvent)	[Reaction:R-HSA-6802935] MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers