Reactome | mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane]

Schema > Complex > Entries

mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - Homo sapiens [Complex:R-HSA-6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs - Homo sapiens
created	[InstanceEdit:6802628] Rothfels, Karen, 2015-10-02
dbId	6802633
displayName	mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane]
hasComponent	[DefinedSet:R-HSA-6802631] genetically or chemically inactive BRAF [cytosol] [Complex:R-HSA-6802621] p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] [Complex:R-HSA-6802607] RAS mutants:GTP [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
maxDepth	5
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1
producedByEvent	[Reaction:R-HSA-6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF - Homo sapiens [Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6802633
updateTrackers	[UpdateTracker:9900780] Update Tracker - [Complex:6802633] mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] - v70:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9900780] Update Tracker - [Complex:6802633] mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] - v70:[updateContainedComponent]
(output)	[Reaction:R-HSA-6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF [Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes
(input)	[Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
(diseaseEntity)	[EntityFunctionalStatus:6802897] gain_of_function of mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane]
(hasComponent)	[Complex:R-HSA-6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802625] RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

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