Reactome | E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798358] Orlic-Milacic, Marija, 2015-09-18
dbId	6798354
displayName	E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-6798348] E2F1 gene [nucleoplasm] [DefinedSet:R-HSA-8953034] E2F7,E2F8 dimers [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:6798350] The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence [LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
maxDepth	4
modified	[InstanceEdit:8953041] Orlic-Milacic, Marija, 2016-12-21
name	E2F7,E2F8 dimers:E2F1 Gene
negativelyRegulates	[NegativeGeneExpressionRegulation:R-HSA-6798356] Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6798354
updateTrackers	[UpdateTracker:9895943] Update Tracker - [Complex:6798354] E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm] - v60:[add_removeHasComponent, modifyName]

(updatedInstance)	[UpdateTracker:9895943] Update Tracker - [Complex:6798354] E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm] - v60:[add_removeHasComponent, modifyName]
(regulator)	[NegativeGeneExpressionRegulation:R-HSA-6798356] Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]'
(output)	[Reaction:R-HSA-6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter