Reactome | PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)

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PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) Show undefined attributes

authored	[InstanceEdit:6784426] D'Eustachio, Peter, 2015-06-19
catalystActivity	[CatalystActivity:6784411] 4-hydroxyglutamate transaminase activity of GOT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9930618] 4-hydroxyglutamate transaminase activity of GOT2 dimer [mitochondrial matrix] Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6784426] D'Eustachio, Peter, 2015-06-19
crossReference	[DatabaseIdentifier:9978928] RHEA:31236
dbId	6784393
deleted	[Deleted:6784428] Deletion of instance: 389859
displayName	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)
edited	[InstanceEdit:6784426] D'Eustachio, Peter, 2015-06-19
eventOf	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-9929459] 4OH-L-Glu [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9930631] Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver [LiteratureReference:8949528] Purification of rat-liver gamma-hydroxyglutamate transaminase and its probable identity with glutamate-aspartate transaminase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate
orthologousEvent	[Reaction:R-DRE-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Danio rerio [Reaction:R-PFA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Plasmodium falciparum [Reaction:R-SCE-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Saccharomyces cerevisiae [Reaction:R-SPO-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Schizosaccharomyces pombe [Reaction:R-DDI-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Dictyostelium discoideum [Reaction:R-CEL-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Caenorhabditis elegans [Reaction:R-DME-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Drosophila melanogaster [Reaction:R-GGA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Gallus gallus [Reaction:R-SSC-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Sus scrofa [Reaction:R-BTA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Bos taurus [Reaction:R-CFA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Canis familiaris [Reaction:R-RNO-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Rattus norvegicus [Reaction:R-MMU-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Mus musculus
output	[SimpleEntity:R-ALL-6784229] HOG [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8953518] Jassal, Bijay, 2016-12-23 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6784393
summation	[Summation:6784400] GOT2 dimer transaminates 4-OH-L-glutamate (4-OH-L-Glu) and 2...
updateTrackers	[UpdateTracker:9939748] Update Tracker - [Reaction:6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - v92:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9939748] Update Tracker - [Reaction:6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - v92:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
(replacementInstances)	[Deleted:6784428] Deletion of instance: 389859
(hasEvent)	[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-HSA-6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

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