Reactome | ALDH3A2-1 oxidises HD2NAL to PALM

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ALDH3A2-1 oxidises HD2NAL to PALM Show undefined attributes

authored	[InstanceEdit:5692240] Jassal, Bijay, 2015-05-11
catalystActivity	[CatalystActivity:5692275] aldehyde dehydrogenase (NAD+) activity of ALDH3A2-1 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643465] aldehyde dehydrogenase (NAD) activity of ALDH3A2-1 dimer [endoplasmic reticulum membrane] Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5692268] Jassal, Bijay, 2015-05-11
dbId	5692261
displayName	ALDH3A2-1 oxidises HD2NAL to PALM
edited	[InstanceEdit:5692240] Jassal, Bijay, 2015-05-11
eventOf	[Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-428671] HD2NAL [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6811625] Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing [LiteratureReference:5692270] Sj�gren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene [LiteratureReference:6811626] Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal [LiteratureReference:6811619] Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization [LiteratureReference:5692267] The Sj�gren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway [LiteratureReference:6811618] Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sj�gren-Larsson syndrome [LiteratureReference:5692274] Spectrum of mutations and sequence variants in the FALDH gene in patients with Sj�gren-Larsson syndrome
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ALDH3A2-1 oxidises HD2NAL to PALM
negativePrecedingEvent	[NegativePrecedingEvent:9841791] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
orthologousEvent	[Reaction:R-SCE-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Saccharomyces cerevisiae [Reaction:R-DDI-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Dictyostelium discoideum [Reaction:R-CEL-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Caenorhabditis elegans [Reaction:R-DME-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Drosophila melanogaster [Reaction:R-GGA-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Gallus gallus [Reaction:R-XTR-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Xenopus tropicalis [Reaction:R-DRE-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Danio rerio [Reaction:R-SSC-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Sus scrofa [Reaction:R-BTA-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Bos taurus [Reaction:R-CFA-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Canis familiaris [Reaction:R-RNO-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Rattus norvegicus [Reaction:R-MMU-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-3632881] PALM [cytosol]
precedingEvent	[Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5692261
summation	[Summation:5692252] Fatty aldehyde dehydrogenase family 3 member A2, isoform 1 (...
updateTrackers	[UpdateTracker:9783393] Update Tracker - [Reaction:5692261] ALDH3A2-1 oxidises HD2NAL to PALM - v56:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783393] Update Tracker - [Reaction:5692261] ALDH3A2-1 oxidises HD2NAL to PALM - v56:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9845614] Sphingolipid catabolism
(precedingEvent)	[NegativePrecedingEvent:9841788] Abundant Molecules: ALDH3A2-1 oxidises HD2NAL to PALM

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