Reactome | Defective pro-SFTPB causes SMDP1 and RDS

Schema > Pathway > Entries

Defective pro-SFTPB causes SMDP1 and RDS Show undefined attributes

authored	[InstanceEdit:5688016] Jassal, Bijay, 2015-04-13
created	[InstanceEdit:5688016] Jassal, Bijay, 2015-04-13
crossReference	[DatabaseIdentifier:12020948] Mondo:0700081
dbId	5688031
disease	[Disease:5683679] newborn respiratory distress syndrome [Disease:5688359] interstitial lung disease
displayName	Defective pro-SFTPB causes SMDP1 and RDS
edited	[InstanceEdit:5688016] Jassal, Bijay, 2015-04-13
eventOf	[Pathway:R-HSA-5687613] Diseases associated with surfactant metabolism - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5688025] Defective pro-SFTPB does not translocate from ER membrane to multivesicle body - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:5688029] Aberrant processing of surfactant protein C in hereditary SP-B deficiency [LiteratureReference:5688032] N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding [LiteratureReference:5688008] Genetic disorders of surfactant dysfunction [LiteratureReference:5683694] Diseases of pulmonary surfactant homeostasis
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Defective pro-SFTPB causes SMDP1 and RDS Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
normalPathway	[Pathway:R-HSA-5683826] Surfactant metabolism
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791021] D'Eustachio, Peter, 2015-08-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5688031
summation	[Summation:5687995] Pulmonary surfactant-associated protein B (SFTPB), amongst o...
updateTrackers	[UpdateTracker:9778517] Update Tracker - [Pathway:5688031] Defective pro-SFTPB causes SMDP1 and RDS - v68:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778517] Update Tracker - [Pathway:5688031] Defective pro-SFTPB causes SMDP1 and RDS - v68:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5687613] Diseases associated with surfactant metabolism

Cite Us!