Reactome | ABCA12 transports lipids from cytosol to extracellular region

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ABCA12 transports lipids from cytosol to extracellular region Show undefined attributes

authored	[InstanceEdit:5682282] Jassal, Bijay, 2015-03-06
catalystActivity	[CatalystActivity:5682284] lipid transporter activity of ABCA12 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5682282] Jassal, Bijay, 2015-03-06
dbId	5682285
diseaseReaction	[FailedReaction:R-HSA-5682311] Defective ABCA12 does not transport lipids from cytosol to extracellular region - Homo sapiens
displayName	ABCA12 transports lipids from cytosol to extracellular region
edited	[InstanceEdit:5682282] Jassal, Bijay, 2015-03-06
eventOf	[Pathway:R-HSA-1369062] ABC transporters in lipid homeostasis - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5682283] lipids [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682337] Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ABCA12 transports lipids from cytosol to extracellular region
orthologousEvent	[Reaction:R-PFA-5682285] ABCA12 transports lipids from cytosol to extracellular region - Plasmodium falciparum [Reaction:R-DDI-5682285] ABCA12 transports lipids from cytosol to extracellular region - Dictyostelium discoideum [Reaction:R-CEL-5682285] ABCA12 transports lipids from cytosol to extracellular region - Caenorhabditis elegans [Reaction:R-DME-5682285] ABCA12 transports lipids from cytosol to extracellular region - Drosophila melanogaster [Reaction:R-GGA-5682285] ABCA12 transports lipids from cytosol to extracellular region - Gallus gallus [Reaction:R-SSC-5682285] ABCA12 transports lipids from cytosol to extracellular region - Sus scrofa [Reaction:R-BTA-5682285] ABCA12 transports lipids from cytosol to extracellular region - Bos taurus [Reaction:R-CFA-5682285] ABCA12 transports lipids from cytosol to extracellular region - Canis familiaris [Reaction:R-RNO-5682285] ABCA12 transports lipids from cytosol to extracellular region - Rattus norvegicus [Reaction:R-MMU-5682285] ABCA12 transports lipids from cytosol to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-5229279] lipids [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6810308] D'Eustachio, Peter, 2015-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682285
summation	[Summation:5682286] ATP-binding cassette sub-family A member 12 (ABCA12) is thou...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5682311] Defective ABCA12 does not transport lipids from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-1369062] ABC transporters in lipid homeostasis