Reactome | KAT5 acetylates ATM at DNA DSBs

Schema > Reaction > Entries

KAT5 acetylates ATM at DNA DSBs Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5682030] acetyltransferase activity of DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682036] Orlic-Milacic, Marija, 2015-03-05
dbId	5682044
displayName	KAT5 acetylates ATM at DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-HSA-3785779] DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682041] A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM [LiteratureReference:5682032] DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity [LiteratureReference:5682049] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 [LiteratureReference:5682136] HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	KAT5 acetylates ATM at DNA DSBs
orthologousEvent	[Reaction:R-MMU-5682044] KAT5 acetylates ATM at DNA DSBs - Mus musculus [Reaction:R-SCE-5682044] KAT5 acetylates ATM at DNA DSBs - Saccharomyces cerevisiae [Reaction:R-SPO-5682044] KAT5 acetylates ATM at DNA DSBs - Schizosaccharomyces pombe [Reaction:R-DDI-5682044] KAT5 acetylates ATM at DNA DSBs - Dictyostelium discoideum [Reaction:R-DME-5682044] KAT5 acetylates ATM at DNA DSBs - Drosophila melanogaster [Reaction:R-GGA-5682044] KAT5 acetylates ATM at DNA DSBs - Gallus gallus [Reaction:R-DRE-5682044] KAT5 acetylates ATM at DNA DSBs - Danio rerio [Reaction:R-SSC-5682044] KAT5 acetylates ATM at DNA DSBs - Sus scrofa [Reaction:R-BTA-5682044] KAT5 acetylates ATM at DNA DSBs - Bos taurus [Reaction:R-CFA-5682044] KAT5 acetylates ATM at DNA DSBs - Canis familiaris [Reaction:R-RNO-5682044] KAT5 acetylates ATM at DNA DSBs - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm] [Complex:R-HSA-5682035] DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693612] MRN complex bound to DNA ends recruits ATM - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682044
summation	[Summation:5682118] The histone acetyltransferase Tip60 (KAT5), in addition to f...
updateTrackers	[UpdateTracker:9775840] Update Tracker - [Reaction:5682044] KAT5 acetylates ATM at DNA DSBs - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775840] Update Tracker - [Reaction:5682044] KAT5 acetylates ATM at DNA DSBs - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks
(precedingEvent)	[Reaction:R-HSA-5693540] MRN activates ATM

Cite Us!