Reactome | ATG3 transfers LC3 from ATG7 to ATG3

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ATG3 transfers LC3 from ATG7 to ATG3 Show undefined attributes

authored	[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
catalystActivity	[CatalystActivity:5682884] Atg8-family ligase activity of CysO572-ATG7-LC3:ATG7:ATG3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5681983] Jupe, Steve, 2015-03-04
dbId	5681981
displayName	ATG3 transfers LC3 from ATG7 to ATG3
edited	[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
eventOf	[Pathway:R-HSA-1632852] Macroautophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-5683593] ATG7:ATG3:LC3 dissociates - Homo sapiens
input	[Complex:R-HSA-9820424] CysO572-ATG7-LC3:ATG7:ATG3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682386] Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p [LiteratureReference:5682890] The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation [LiteratureReference:5679189] Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ATG3 transfers LC3 from ATG7 to ATG3
orthologousEvent	[Reaction:R-MMU-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Mus musculus [Reaction:R-RNO-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Rattus norvegicus [Reaction:R-PFA-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Plasmodium falciparum [Reaction:R-SCE-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Saccharomyces cerevisiae [Reaction:R-SPO-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Schizosaccharomyces pombe [Reaction:R-DDI-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Dictyostelium discoideum [Reaction:R-CEL-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Caenorhabditis elegans [Reaction:R-DME-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Drosophila melanogaster [Reaction:R-GGA-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Gallus gallus [Reaction:R-XTR-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Xenopus tropicalis [Reaction:R-SSC-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Sus scrofa [Reaction:R-BTA-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Bos taurus [Reaction:R-CFA-5681981] ATG3 transfers LC3 from ATG7 to ATG3 - Canis familiaris
output	[Complex:R-HSA-9820425] CysO264-ATG3-LC3:ATG7 dimer [cytosol]
precedingEvent	[Reaction:R-HSA-5682896] LC3:ATG7 dimer binds ATG3 - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13 [InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5681981
summation	[Summation:5681979] The activated LC3 protein is transferred to Cys-263 of ATG3 ...
updateTrackers	[UpdateTracker:9846899] Update Tracker - [Reaction:5681981] ATG3 transfers LC3 from ATG7 to ATG3 - v83:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9846899] Update Tracker - [Reaction:5681981] ATG3 transfers LC3 from ATG7 to ATG3 - v83:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-1632852] Macroautophagy
(precedingEvent)	[Reaction:R-HSA-5683593] ATG7:ATG3:LC3 dissociates

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