Reactome | CLEC7A/inflammasome pathway

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CLEC7A/inflammasome pathway Show undefined attributes

authored	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5660669] Garapati, P V, 2015-01-04
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407
dbId	5660668
displayName	CLEC7A/inflammasome pathway
edited	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
eventOf	[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5660622] IL1B gene is transcribed - Homo sapiens [Reaction:R-HSA-5660665] Caspase-8 binds MALT - Homo sapiens [Reaction:R-HSA-5660662] ASC binds Caspase-8 complex - Homo sapiens [Reaction:R-HSA-5660663] Caspase-8 cleaves IL1B precursor - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5660611] Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome [LiteratureReference:5660589] The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	CLEC7A/inflammasome pathway
orthologousEvent	[Pathway:R-RNO-5660668] CLEC7A/inflammasome pathway - Rattus norvegicus [Pathway:R-GGA-5660668] CLEC7A/inflammasome pathway - Gallus gallus [Pathway:R-SSC-5660668] CLEC7A/inflammasome pathway - Sus scrofa [Pathway:R-BTA-5660668] CLEC7A/inflammasome pathway - Bos taurus [Pathway:R-CFA-5660668] CLEC7A/inflammasome pathway - Canis familiaris [Pathway:R-MMU-5660668] CLEC7A/inflammasome pathway - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5660668
summation	[Summation:5660587] Antifungal immunity through the induction of T-helper 17 cel...

Referrals

(hasEvent)

[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling