Reactome | SPRED dimer binds NF1

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SPRED dimer binds NF1 Show undefined attributes

authored	[InstanceEdit:5656286] Rothfels, Karen, 2014-12-11
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5658439] Rothfels, Karen, 2014-12-18
dbId	5658438
displayName	SPRED dimer binds NF1
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs - Homo sapiens
followingEvent	[Reaction:R-HSA-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-947770] NF1(2-2839) [cytosol] [CandidateSet:R-HSA-5658219] SPRED dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5658429] Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation [LiteratureReference:5658411] Eve-3: a liver enriched suppressor of Ras/MAPK signaling [LiteratureReference:5658239] A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1 [LiteratureReference:5658443] The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 [LiteratureReference:5658427] Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells [LiteratureReference:5658436] Ras regulation. NF is enough of GAP [LiteratureReference:5658407] Distinct requirements for the Sprouty domain for functional activity of Spred proteins [LiteratureReference:5658441] Spred is a Sprouty-related suppressor of Ras signalling [LiteratureReference:5653735] SPRED proteins provide a NF-ty link to Ras suppression [LiteratureReference:5658403] An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SPRED dimer binds NF1
orthologousEvent	[Reaction:R-RNO-5658438] SPRED dimer binds NF1 - Rattus norvegicus [Reaction:R-DDI-5658438] SPRED dimer binds NF1 - Dictyostelium discoideum [Reaction:R-DME-5658438] SPRED dimer binds NF1 - Drosophila melanogaster [Reaction:R-GGA-5658438] SPRED dimer binds NF1 - Gallus gallus [Reaction:R-DRE-5658438] SPRED dimer binds NF1 - Danio rerio [Reaction:R-SSC-5658438] SPRED dimer binds NF1 - Sus scrofa [Reaction:R-CFA-5658438] SPRED dimer binds NF1 - Canis familiaris [Reaction:R-MMU-5658438] SPRED dimer binds NF1 - Mus musculus
output	[Complex:R-HSA-5658232] SPRED dimer:NF1 [plasma membrane]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5658438
summation	[Summation:5658440] Sprouty-related proteins (SPRED) 1, 2 and 3 are negative reg...

Referrals

(hasEvent)	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs
(precedingEvent)	[Reaction:R-HSA-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1

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