Reactome | MGMT binds alkylated DNA containing 6-O-methylguanine

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MGMT binds alkylated DNA containing 6-O-methylguanine Show undefined attributes

authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15
dbId	5657651
displayName	MGMT binds alkylated DNA containing 6-O-methylguanine
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
eventOf	[Pathway:R-HSA-5657655] MGMT-mediated DNA damage reversal - Homo sapiens
followingEvent	[Reaction:R-HSA-73892] MGMT/hAGT mediated DNA Damage Reversal - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17672] DNA alkylation repair
input	[GenomeEncodedEntity:R-HSA-5657606] 6-OMeG-dsDNA [nucleoplasm] [Complex:R-HSA-5657631] MGMT:Zn2+ [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69939] Regulation of repair of alkylation damage in mammalian genomes. [LiteratureReference:5657611] Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding [LiteratureReference:5657661] The structure of the human AGT protein bound to DNA and its implications for damage detection [LiteratureReference:5657623] A new model for how O6-methylguanine-DNA methyltransferase binds DNA
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MGMT binds alkylated DNA containing 6-O-methylguanine
output	[Complex:R-HSA-5657662] MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9732692] Triazenes produce DNA damage in the form of O6-methylguanine - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
revised	[InstanceEdit:5657608] Orlic-Milacic, Marija, 2014-12-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5657651
summation	[Summation:5657664] MGMT recognizes and binds DNA containing 6-O-methylguanine i...

Referrals

(precedingEvent)	[Reaction:R-HSA-73892] MGMT/hAGT mediated DNA Damage Reversal
(hasEvent)	[Pathway:R-HSA-5657655] MGMT-mediated DNA damage reversal

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