Reactome | Activated FGFR3 phosphorylates FRS3

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Activated FGFR3 phosphorylates FRS3 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654629] protein tyrosine kinase activity of Activated FGFR3:FRS3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654627] Rothfels, Karen, 2014-12-03
dbId	5654628
deleted	[Deleted:5655566] Deletion of instance: 191471
displayName	Activated FGFR3 phosphorylates FRS3
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654633] Activated FGFR3:p-FRS bind to PPTN11 - Homo sapiens
input	[Complex:R-HSA-5654297] Activated FGFR3:FRS3 [plasma membrane] 5 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR3 phosphorylates FRS3
orthologousEvent	[Reaction:R-CEL-5654628] Activated FGFR3 phosphorylates FRS3 - Caenorhabditis elegans [Reaction:R-DME-5654628] Activated FGFR3 phosphorylates FRS3 - Drosophila melanogaster [Reaction:R-GGA-5654628] Activated FGFR3 phosphorylates FRS3 - Gallus gallus [Reaction:R-XTR-5654628] Activated FGFR3 phosphorylates FRS3 - Xenopus tropicalis [Reaction:R-DRE-5654628] Activated FGFR3 phosphorylates FRS3 - Danio rerio [Reaction:R-BTA-5654628] Activated FGFR3 phosphorylates FRS3 - Bos taurus [Reaction:R-CFA-5654628] Activated FGFR3 phosphorylates FRS3 - Canis familiaris [Reaction:R-RNO-5654628] Activated FGFR3 phosphorylates FRS3 - Rattus norvegicus [Reaction:R-MMU-5654628] Activated FGFR3 phosphorylates FRS3 - Mus musculus
output	[Complex:R-HSA-5654303] Activated FGFR3:p-FRS3 [plasma membrane] 5 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5654623] Activated FGFR3 binds FRS3 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654628
summation	[Summation:191523] FRS3 (also known as FRS2 beta) is activated through tyrosine...

Referrals

(replacementInstances)	[Deleted:5655566] Deletion of instance: 191471
(hasEvent)	[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling
(precedingEvent)	[Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 [Reaction:R-HSA-5654633] Activated FGFR3:p-FRS bind to PPTN11