Reactome | POLD,POLE complete replication of damaged DNA after TLS

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POLD,POLE complete replication of damaged DNA after TLS Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5653836] DNA-directed DNA polymerase activity of PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5653839] Orlic-Milacic, Marija, 2014-12-02
dbId	5653840
displayName	POLD,POLE complete replication of damaged DNA after TLS
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-5656169] Termination of translesion DNA synthesis - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-HSA-5653837] PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5653648] Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLD,POLE complete replication of damaged DNA after TLS
output	[DefinedSet:R-HSA-5652135] Damaged dsDNA [nucleoplasm] [Complex:R-HSA-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5653838] POLD,POLE binds deISGylated PCNA after TLS - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5653840
summation	[Summation:5653815] After DNA damage is bypassed by error-prone DNA polymerases ...

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[Pathway:R-HSA-5656169] Termination of translesion DNA synthesis

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