Reactome | HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH

Schema > Reaction > Entries

authored	[InstanceEdit:5629221] May, Bruce, 2014-10-25
catalystActivity	[CatalystActivity:5601913] O-methyltransferase activity of HENMT1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5629235] May, Bruce, 2014-10-25
dbId	5629203
displayName	HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH
edited	[InstanceEdit:5629221] May, Bruce, 2014-10-25
eventOf	[Pathway:R-HSA-5601884] PIWI-interacting RNA (piRNA) biogenesis - Homo sapiens
inferredFrom	[Reaction:R-MMU-5629239] Henmt1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-Piwil1:piRNA:Tdrd6:Tdrkh - Mus musculus
input	[Complex:R-HSA-5629240] 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH
output	[Complex:R-HSA-5603059] 4xMeR-PIWIL1:2'-O-methyl-piRNA:TDRD6:TDRKH [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5601888] Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5629251] Saito, Kuniaki, 2014-10-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5629203
summation	[Summation:5629209] As inferred from mouse homologs, HENMT1 transfers a methyl g...

(hasEvent)	[Pathway:R-HSA-5601884] PIWI-interacting RNA (piRNA) biogenesis
(inferredTo)	[Reaction:R-MMU-5629239] Henmt1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-Piwil1:piRNA:Tdrd6:Tdrkh

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