Reactome | ARL13B-mediated ciliary trafficking of INPP5E

Schema > Pathway > Entries

ARL13B-mediated ciliary trafficking of INPP5E Show undefined attributes

authored	[InstanceEdit:5624166] Rothfels, Karen, 2014-09-19
created	[InstanceEdit:5624957] Rothfels, Karen, 2014-09-30
dbId	5624958
displayName	ARL13B-mediated ciliary trafficking of INPP5E
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620920] Cargo trafficking to the periciliary membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:376831] cilium assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5624956] PDE6D binds INPP5E - Homo sapiens [BlackBoxEvent:R-HSA-5624954] INPP5E translocates to the primary cilium - Homo sapiens [Reaction:R-HSA-5624953] ARL13B binds INPP5E - Homo sapiens [Reaction:R-HSA-5638012] PDE6D dissociates from ARL13B:INPP5E - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:5624812] Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation [LiteratureReference:5624829] Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome [LiteratureReference:5624808] Clinical and molecular features of Joubert syndrome and related disorders [LiteratureReference:5624822] Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans [LiteratureReference:5624017] The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis [LiteratureReference:5624804] Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain [LiteratureReference:5623331] The emerging role of Arf/Arl small GTPases in cilia and ciliopathies [LiteratureReference:5624827] Molecular views of Arf-like small GTPases in cilia and ciliopathies [LiteratureReference:5624801] ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting [LiteratureReference:5624799] A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium [LiteratureReference:1675802] Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies [LiteratureReference:5624816] INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse [LiteratureReference:5624817] Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ARL13B-mediated ciliary trafficking of INPP5E
orthologousEvent	[Pathway:R-GGA-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Gallus gallus [Pathway:R-SSC-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Sus scrofa [Pathway:R-BTA-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Bos taurus [Pathway:R-CFA-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Canis familiaris [Pathway:R-RNO-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Rattus norvegicus [Pathway:R-MMU-5624958] ARL13B-mediated ciliary trafficking of INPP5E - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5624958
summation	[Summation:5624837] ARL13B is a ciliary-localized small GTPase with an atypical ...
updateTrackers	[UpdateTracker:9782645] Update Tracker - [Pathway:5624958] ARL13B-mediated ciliary trafficking of INPP5E - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782645] Update Tracker - [Pathway:5624958] ARL13B-mediated ciliary trafficking of INPP5E - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-5620920] Cargo trafficking to the periciliary membrane

Cite Us!