Reactome | 4xub-p13S-Gli3:SUFU [ciliary base]

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4xub-p13S-Gli3:SUFU [ciliary base] Show undefined attributes

compartment	[Compartment:5263232] ciliary base
consumedByEvent	[BlackBoxEvent:R-HSA-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor - Homo sapiens
created	[InstanceEdit:5610527] Rothfels, Karen, 2014-07-22
dbId	5610526
displayName	4xub-p13S-Gli3:SUFU [ciliary base]
hasComponent	[EntityWithAccessionedSequence:R-HSA-5610424] SUFU [ciliary base] [EntityWithAccessionedSequence:R-HSA-5610506] ub-p13S-GLI3 [ciliary base]
inDisease	false
inferredTo	[Complex:R-MMU-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Mus musculus [Complex:R-RNO-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Rattus norvegicus [Complex:R-CFA-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Canis familiaris [Complex:R-BTA-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Bos taurus [Complex:R-SSC-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Sus scrofa [Complex:R-DRE-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Danio rerio [Complex:R-XTR-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Xenopus tropicalis [Complex:R-GGA-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Gallus gallus [Complex:R-DME-5610526] 4xub-p13S-Gli3:SUFU [ciliary base] - Drosophila melanogaster
isChimeric	false
literatureReference	[LiteratureReference:5609719] Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing [LiteratureReference:208141] Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
maxDepth	2
modified	[InstanceEdit:5625159] D'Eustachio, Peter, 2014-10-02
name	4xub-p13S-Gli3:SUFU
producedByEvent	[Reaction:R-HSA-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5610526

Referrals

(output)	[Reaction:R-HSA-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3
(input)	[BlackBoxEvent:R-HSA-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor

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