Reactome | CYP3A4,5 hydroxylates AFB1 to AFQ1

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CYP3A4,5 hydroxylates AFB1 to AFQ1 Show undefined attributes

authored	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
catalystActivity	[CatalystActivity:5423671] monooxygenase activity of CYP3A4,5 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
dbId	5423664
displayName	CYP3A4,5 hydroxylates AFB1 to AFQ1
edited	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
eventOf	[Pathway:R-HSA-5423646] Aflatoxin activation and detoxification - Homo sapiens
input	[SimpleEntity:R-ALL-5423605] AFB1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5423613] The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 [LiteratureReference:5423655] Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography [LiteratureReference:5490290] Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP3A4,5 hydroxylates AFB1 to AFQ1
orthologousEvent	[Reaction:R-GGA-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Gallus gallus [Reaction:R-XTR-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Xenopus tropicalis [Reaction:R-DRE-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Danio rerio [Reaction:R-SSC-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Sus scrofa [Reaction:R-BTA-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Bos taurus [Reaction:R-CFA-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Canis familiaris [Reaction:R-RNO-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Rattus norvegicus [Reaction:R-MMU-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Mus musculus
output	[SimpleEntity:R-ALL-5423660] AFQ1 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5545505] D'Eustachio, Peter, 2014-05-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5423664
summation	[Summation:5423674] Metabolites that are formed from aflatoxin B1 (AFB1) include...

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(hasEvent)

[Pathway:R-HSA-5423646] Aflatoxin activation and detoxification