Reactome | PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion

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PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion Show undefined attributes

authored	[InstanceEdit:5340172] Rothfels, K, 2014-03-11
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5340559] Rothfels, K, 2014-03-19
dbId	5340560
disease	[Disease:1500689] cancer
displayName	PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-5340573] LGK974 inhibits PORCN - Homo sapiens
input	[ChemicalDrug:R-ALL-5340556] LGK974 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-3238209] PORCN [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:3238090] Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein [LiteratureReference:3238084] The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing [LiteratureReference:3238075] A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling [LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases [LiteratureReference:3238093] Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion [LiteratureReference:3238086] Structural basis of Wnt recognition by Frizzled [LiteratureReference:3247710] Porcupine-mediated lipidation is required for Wnt recognition by Wls [LiteratureReference:3247729] Lipid-independent secretion of a Drosophila Wnt protein [LiteratureReference:3238078] A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities [LiteratureReference:3247704] Precise regulation of porcupine activity is required for physiological Wnt signaling [LiteratureReference:5340554] Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion
output	[Complex:R-HSA-5340557] PORCN:LGK974 [endoplasmic reticulum membrane]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5340560
summation	[Summation:5340558] Porcupine (PORCN) is an O-acyl-transferase that catalyzes th...

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[Pathway:R-HSA-5340573] LGK974 inhibits PORCN