Reactome | HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol

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HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol Show undefined attributes

authored	[InstanceEdit:5252021] Jassal, Bijay, 2014-02-05
catalystActivity	[CatalystActivity:5252050] ATPase activator activity of DNAJB1,B6,C2,C7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5252021] Jassal, Bijay, 2014-02-05
dbId	5251959
displayName	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
edited	[InstanceEdit:5252021] Jassal, Bijay, 2014-02-05
eventOf	[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [CandidateSet:R-HSA-5252049] HSP70s:ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5252135] Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells [LiteratureReference:5255381] A human homologue of the Escherichia coli DnaJ heat-shock protein [LiteratureReference:5255351] The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity [LiteratureReference:5255374] Characterization of two isoforms of a human DnaJ homologue, HSJ2 [LiteratureReference:5255362] Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein [LiteratureReference:5255364] Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous [LiteratureReference:5255373] Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
orthologousEvent	[Reaction:R-PFA-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Plasmodium falciparum [Reaction:R-SCE-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Saccharomyces cerevisiae [Reaction:R-SPO-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Schizosaccharomyces pombe [Reaction:R-DDI-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Dictyostelium discoideum [Reaction:R-CEL-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Caenorhabditis elegans [Reaction:R-DME-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Drosophila melanogaster [Reaction:R-XTR-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Xenopus tropicalis [Reaction:R-DRE-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Danio rerio [Reaction:R-SSC-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Sus scrofa [Reaction:R-BTA-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Bos taurus [Reaction:R-CFA-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Canis familiaris [Reaction:R-RNO-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Rattus norvegicus [Reaction:R-MMU-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Mus musculus
output	[CandidateSet:R-HSA-5252057] HSP70s:ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-5252079] HSP110s exchange ATP for ADP on HSP70s:ADP - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5674208] D'Eustachio, Peter, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5251959
summation	[Summation:5255360] Heat-shock 70kDa proteins (HSP70s) are a family of conserved...

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(hasEvent)

[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response

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