Reactome | botF LC cleaves target cell VAMP2

Schema > Reaction > Entries

botF LC cleaves target cell VAMP2 Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:194817] metalloendopeptidase activity of botF LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643353] metalloendopeptidase activity of BoNT/F LC:Zn2+ [cytosol] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
category	transition
compartment	[Compartment:201753] synaptic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:5250893] D'Eustachio, Peter, 2014-01-30
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5250892
deleted	[Deleted:5250998] Deletion of instance: 168769
disease	[Disease:3632909] botulism
displayName	botF LC cleaves target cell VAMP2
edited	[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
eventOf	[Pathway:R-HSA-5250981] Toxicity of botulinum toxin type F (botF) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-181517] VAMP2 [synaptic vesicle membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:181778] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botF LC cleaves target cell VAMP2
output	[EntityWithAccessionedSequence:R-HSA-194815] VAMP2(2-58) [cytosol] [EntityWithAccessionedSequence:R-HSA-5250891] VAMP2(59-116) [synaptic vesicle membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5250884] botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5250892
summation	[Summation:5263570] Botulinum toxin type F light chain (botF LC), in the cytosol...
updateTrackers	[UpdateTracker:9786237] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v50:[modifyText] [UpdateTracker:9776575] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786237] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v50:[modifyText] [UpdateTracker:9776575] Update Tracker - [Reaction:5250892] botF LC cleaves target cell VAMP2 - v75:[modifyText]
(replacementInstances)	[Deleted:5250998] Deletion of instance: 168769
(hasEvent)	[Pathway:R-HSA-5250981] Toxicity of botulinum toxin type F (botF)