Reactome | SLC22A17 binds LCN2:2,5DHBA:Fe3+

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SLC22A17 binds LCN2:2,5DHBA:Fe3+ Show undefined attributes

authored	[InstanceEdit:5246456] Jassal, Bijay, 2014-01-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:5246456] Jassal, Bijay, 2014-01-21
dbId	5246444
displayName	SLC22A17 binds LCN2:2,5DHBA:Fe3+
edited	[InstanceEdit:5246456] Jassal, Bijay, 2014-01-21
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-5246466] Slc22a17 binds Lcn2, internalising it, releasing Fe3+ - Mus musculus
input	[Complex:R-HSA-5229238] LCN2:2,5DHBA:Fe3+ [extracellular region] [EntityWithAccessionedSequence:R-HSA-561099] SLC22A17 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5229275] The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition [LiteratureReference:5246450] Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron [LiteratureReference:5246451] A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC22A17 binds LCN2:2,5DHBA:Fe3+
output	[Complex:R-HSA-5246491] SLC22A17:LCN2:2,5DHBA:Fe3+ [plasma membrane]
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5580221] Chen, Caiyong, 2014-06-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5246444
summation	[Summation:5246468] Neutrophil gelatinase-associated lipocalin (LCN2, NGAL) is a...
updateTrackers	[UpdateTracker:9785443] Update Tracker - [Reaction:5246444] SLC22A17 binds LCN2:2,5DHBA:Fe3+ - v52:[removeCatalystActivity, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9785443] Update Tracker - [Reaction:5246444] SLC22A17 binds LCN2:2,5DHBA:Fe3+ - v52:[removeCatalystActivity, removeOutput]
(hasEvent)	[Pathway:R-HSA-917937] Iron uptake and transport
(inferredTo)	[BlackBoxEvent:R-MMU-5246466] Slc22a17 binds Lcn2, internalising it, releasing Fe3+

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