Reactome | botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]

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botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] Show undefined attributes

catalystActivities	[CatalystActivity:5244412] protein transmembrane transporter activity of botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]
compartment	[Compartment:201753] synaptic vesicle membrane
consumedByEvent	[BlackBoxEvent:R-HSA-5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens
created	[InstanceEdit:5244505] D'Eustachio, Peter, 2014-01-18
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5244507
deleted	[Deleted:5250997] Deletion of instance: 181477 [Deleted:5251000] Deletion of instance: 194804
disease	[Disease:3632909] botulism
displayName	botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]
goCellularComponent	[Compartment:5251407] host cell synaptic vesicle membrane
hasComponent	[Complex:R-CBO-5228950] botA HC:LC dimer [synaptic vesicle membrane] [SimpleEntity:R-ALL-5244439] GT1b [synaptic vesicle membrane] [DefinedSet:R-HSA-5324682] SV2A,B,C [synaptic vesicle membrane]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:5228575] Crystal structure of botulinum neurotoxin type A and implications for toxicity
maxDepth	4
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botA HC:LC dimer:SV2:GT1b BoNT/A:SV2:GT1b
producedByEvent	[BlackBoxEvent:R-HSA-5244424] botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5244507
updateTrackers	[UpdateTracker:9901803] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v75:[addName, updateContainedComponent] [UpdateTracker:9896606] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v60:[removeSpecies] [UpdateTracker:9899515] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v66:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9901803] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v75:[addName, updateContainedComponent] [UpdateTracker:9896606] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v60:[removeSpecies] [UpdateTracker:9899515] Update Tracker - [Complex:5244507] botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] - v66:[updateContainedComponent]
(replacementInstances)	[Deleted:5250997] Deletion of instance: 181477 [Deleted:5251000] Deletion of instance: 194804
(output)	[BlackBoxEvent:R-HSA-5244424] botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane
(input)	[BlackBoxEvent:R-HSA-5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol
(physicalEntity)	[CatalystActivity:5244412] protein transmembrane transporter activity of botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane]