Reactome | botE HC:LC binds SV2A or B and GT1b on the target cell surface

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botE HC:LC binds SV2A or B and GT1b on the target cell surface Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5244505] D'Eustachio, Peter, 2014-01-18
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5244503
deleted	[Deleted:5251022] Deletion of instance: 181359
disease	[Disease:3632909] botulism
displayName	botE HC:LC binds SV2A or B and GT1b on the target cell surface
eventOf	[Pathway:R-HSA-5250992] Toxicity of botulinum toxin type E (botE) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5244500] botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
input	[Complex:R-CBO-5228686] botE HC:LC dimer [extracellular region] [SimpleEntity:R-ALL-5244403] GT1b [plasma membrane] [DefinedSet:R-HSA-5324689] SV2A,B [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5244433] Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons [LiteratureReference:5262579] Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation [LiteratureReference:5244438] Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botE HC:LC binds SV2A or B and GT1b on the target cell surface
output	[Complex:R-HSA-5244512] botE:SV2:GT1b [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5228941] Transcytosis and dissociation of botE:NTNHA - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5244503
summation	[Summation:5262583] The Botulinum toxin type E disulfide bonded heavy chain - li...
updateTrackers	[UpdateTracker:9776518] Update Tracker - [Reaction:5244503] botE HC:LC binds SV2A or B and GT1b on the target cell surface - v75:[modifyText] [UpdateTracker:9786348] Update Tracker - [Reaction:5244503] botE HC:LC binds SV2A or B and GT1b on the target cell surface - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776518] Update Tracker - [Reaction:5244503] botE HC:LC binds SV2A or B and GT1b on the target cell surface - v75:[modifyText] [UpdateTracker:9786348] Update Tracker - [Reaction:5244503] botE HC:LC binds SV2A or B and GT1b on the target cell surface - v50:[modifyText]
(replacementInstances)	[Deleted:5251022] Deletion of instance: 181359
(hasEvent)	[Pathway:R-HSA-5250992] Toxicity of botulinum toxin type E (botE)
(precedingEvent)	[BlackBoxEvent:R-HSA-5244500] botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

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