Reactome | botB HC:LC dimer:SYT:GT1b [plasma membrane]

Schema > Complex > Entries

botB HC:LC dimer:SYT:GT1b [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-HSA-5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
created	[InstanceEdit:5244399] D'Eustachio, Peter, 2014-01-17
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5244408
deleted	[Deleted:5251026] Deletion of instance: 181532
disease	[Disease:3632909] botulism
displayName	botB HC:LC dimer:SYT:GT1b [plasma membrane]
goCellularComponent	[GO_CellularComponent:6485] host cell plasma membrane
hasComponent	[Complex:R-CBO-5228954] botB HC:LC dimer [plasma membrane] [SimpleEntity:R-ALL-5244403] GT1b [plasma membrane] [DefinedSet:R-HSA-5324686] SYT1,2 [plasma membrane]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:194828] Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells [LiteratureReference:5244426] Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins
maxDepth	4
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botB HC:LC dimer:SYT:GT1b BoNT/B:SYT:GT1b
producedByEvent	[Reaction:R-HSA-5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5244408
updateTrackers	[UpdateTracker:9901797] Update Tracker - [Complex:5244408] botB HC:LC dimer:SYT:GT1b [plasma membrane] - v75:[addName, updateContainedComponent] [UpdateTracker:9896303] Update Tracker - [Complex:5244408] botB HC:LC dimer:SYT:GT1b [plasma membrane] - v60:[removeSpecies]

Referrals

(updatedInstance)	[UpdateTracker:9901797] Update Tracker - [Complex:5244408] botB HC:LC dimer:SYT:GT1b [plasma membrane] - v75:[addName, updateContainedComponent] [UpdateTracker:9896303] Update Tracker - [Complex:5244408] botB HC:LC dimer:SYT:GT1b [plasma membrane] - v60:[removeSpecies]
(replacementInstances)	[Deleted:5251026] Deletion of instance: 181532
(output)	[Reaction:R-HSA-5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface
(input)	[BlackBoxEvent:R-HSA-5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane