Reactome | PTK2 autophosphorylates

Schema > Reaction > Entries

PTK2 autophosphorylates Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:5218644] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644029] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] Alternative splicing controls the mechanisms of FAK autophosphorylation
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5218634] Garapati, P V, 2013-12-19
dbId	5218642
displayName	PTK2 autophosphorylates
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-5218645] SRC-1 binds p-Y397-PTK2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-4420141] VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218443] Alternative splicing controls the mechanisms of FAK autophosphorylation [LiteratureReference:372691] Focal adhesion kinase: in command and control of cell motility
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PTK2 autophosphorylates
orthologousEvent	[Reaction:R-GGA-5218642] PTK2 autophosphorylates - Gallus gallus [Reaction:R-XTR-5218642] PTK2 autophosphorylates - Xenopus tropicalis [Reaction:R-SSC-5218642] PTK2 autophosphorylates - Sus scrofa [Reaction:R-BTA-5218642] PTK2 autophosphorylates - Bos taurus [Reaction:R-CFA-5218642] PTK2 autophosphorylates - Canis familiaris [Reaction:R-RNO-5218642] PTK2 autophosphorylates - Rattus norvegicus [Reaction:R-MMU-5218642] PTK2 autophosphorylates - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5218639] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5218642
summation	[Summation:5218356] Six tyrosine phosphorylation sites in focal adhesion kinase ...

Referrals

(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-5218645] SRC-1 binds p-Y397-PTK2