Reactome | Signaling by APC mutants

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Signaling by APC mutants Show undefined attributes

authored	[InstanceEdit:4839725] Rothfels, K, 2013-11-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839745] Rothfels, K, 2013-11-02
dbId	4839744
disease	[Disease:1500689] cancer
displayName	Signaling by APC mutants
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4791275] Signaling by WNT in cancer - Homo sapiens
figure	[Figure:9758325] /figures/ehld/R-HSA-4839744.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5467333] APC truncation mutants are not K63 polyubiquitinated - Homo sapiens [Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:5228658] Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the ?-catenin destruction complex [LiteratureReference:196265] Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation [LiteratureReference:5251537] The ?-catenin destruction complex [LiteratureReference:5251476] Colorectal cancer and genetic alterations in the Wnt pathway [LiteratureReference:5251489] Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene [LiteratureReference:4791254] Mutations of the APC (adenomatous polyposis coli) gene [LiteratureReference:5251477] Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma [LiteratureReference:3299531] XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos [LiteratureReference:5246621] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC [LiteratureReference:5246618] Wnt signaling and cancer
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by APC mutants
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4839744
summation	[Summation:5251516] APC is a large and central component of the destruction comp...

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[Pathway:R-HSA-4791275] Signaling by WNT in cancer

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