Reactome | SAHF formation

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SAHF formation Show undefined attributes

authored	[InstanceEdit:4648961] Orlic-Milacic, M, 2013-09-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4647599] Orlic-Milacic, M, 2013-09-30
dbId	4647594
displayName	SAHF formation
edited	[InstanceEdit:5093949] Orlic-Milacic, M, 2013-11-08
eventOf	[Pathway:R-HSA-2559584] Formation of Senescence-Associated Heterochromatin Foci (SAHF) - Homo sapiens
input	[Complex:R-HSA-3878132] HIRA:ASF1A:UBN1:CABIN1 [nucleoplasm] [Complex:R-HSA-211238] Histone H1 bound chromatin DNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3004623] HMGA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1629831] HMGA2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4647592] Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence [LiteratureReference:3878196] A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation [LiteratureReference:4647608] The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway [LiteratureReference:3878194] Loss of linker histone H1 in cellular senescence [LiteratureReference:3878148] Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA [LiteratureReference:3878192] Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci [LiteratureReference:3878156] Molecular dissection of formation of senescence-associated heterochromatin foci
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SAHF formation
orthologousEvent	[Reaction:R-RNO-4647594] SAHF formation - Rattus norvegicus [Reaction:R-CEL-4647594] SAHF formation - Caenorhabditis elegans [Reaction:R-GGA-4647594] SAHF formation - Gallus gallus [Reaction:R-SSC-4647594] SAHF formation - Sus scrofa [Reaction:R-CFA-4647594] SAHF formation - Canis familiaris [Reaction:R-MMU-4647594] SAHF formation - Mus musculus
output	[CandidateSet:R-HSA-211243] Histone H1 [nucleoplasm] [Complex:R-HSA-4647600] SAHF [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3878123] Initiation of SAHF formation - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-4647603] Negative regulation by 'LMNB1 [nucleoplasm]' [NegativeRegulation:R-HSA-4647607] Negative regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' [PositiveRegulation:R-HSA-4648284] Positive regulation by 'RB1 [nucleoplasm]' [PositiveRegulation:R-HSA-4648285] Positive regulation by 'p-S15-TP53 Tetramer [nucleoplasm]'
regulationReference	[RegulationReference:9641256] Positive regulation by 'p-S15-TP53 Tetramer [nucleoplasm]' Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci [RegulationReference:9642135] Positive regulation by 'RB1 [nucleoplasm]' Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci [RegulationReference:9642846] Negative regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway [RegulationReference:9642919] Negative regulation by 'LMNB1 [nucleoplasm]' Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4647594
summation	[Summation:4648286] Components of the evolutionarily conserved complex of HIRA, ...

Referrals

(hasEvent)

[Pathway:R-HSA-2559584] Formation of Senescence-Associated Heterochromatin Foci (SAHF)

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